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Antigen-presenting cell-derived IL-6 restricts the expression of GATA3 and IL-4 by follicular helper T cells

Follicular helper T cells (Tfh) support high-affinity Ab production by germinal center B cells through both membrane interactions and secretion of IL-4 and -21, two major cytokines implicated in B-cell survival and Ab class switch. Tfh-2 cells recently emerged in humans as a strong IL-4 producer Tfh...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Leukoc Biol
Prif Awduron: Hercor, Mélanie, Anciaux, Maelle, Denanglaire, Sébastien, Debuisson, Delphine, Leo, Oberdan, Andris, Fabienne
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Leukocyte Biology 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5166434/
https://ncbi.nlm.nih.gov/pubmed/27474166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1HI1115-511R
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