Structure of heptameric protective antigen bound to an anthrax toxin receptor: A role for receptor in pH-dependent pore formation

After binding to cellular receptors and proteolytic activation, the protective antigen component of anthrax toxin forms a heptameric prepore. The prepore later undergoes pH-dependent conversion to a pore, mediating translocation of the edema and lethal factors to the cytosol. We describe structures...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Lacy, D. Borden, Wigelsworth, Darran J., Melnyk, Roman A., Harrison, Stephen C., Collier, R. John
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 2004
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC516539/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15326297/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0405405101
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