Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I(2) receptor IP

Persistent reduction of renal perfusion pressure induces renovascular hypertension by activating the renin-angiotensin-aldosterone system; however, the sensing mechanism remains elusive. Here we investigated the role of PGI(2) in renovascular hypertension in vivo, employing mice lacking the PGI(2) r...

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Autores principales: Fujino, Takayuki, Nakagawa, Naoki, Yuhki, Koh-ichi, Hara, Akiyoshi, Yamada, Takehiro, Takayama, Koji, Kuriyama, Shuhko, Hosoki, Yayoi, Takahata, Osamu, Taniguchi, Takanobu, Fukuzawa, Jun, Hasebe, Naoyuki, Kikuchi, Kenjiro, Narumiya, Shuh, Ushikubi, Fumitaka
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2004
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC516260/
https://ncbi.nlm.nih.gov/pubmed/15372104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421382
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