Diet restriction delays accelerated aging and genomic stress in DNA repair deficient mice

DNA repair-deficient Ercc1(Δ/−) mice show numerous accelerated aging features limiting lifespan to 4–6 month(1–4). Simultaneously they exhibit a ‘survival response’, which suppresses growth and enhances maintenance, resembling the anti-aging response induced by dietary restriction (DR)(1,5). Here we...

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Publié dans:Nature
Auteurs principaux: Vermeij, W.P., Dollé, M.E.T., Reiling, E., Jaarsma, D., Payan-Gomez, C., Bombardieri, C.R., Wu, H., Roks, A.J.M., Botter, S.M., van der Eerden, B.C., Youssef, S.A., Kuiper, R.V., Nagarajah, B., van Oostrom, C.T., Brandt, R.M.C., Barnhoorn, S., Imholz, S., Pennings, J.L.A., de Bruin, A., Gyenis, Á., Pothof, J., Vijg, J., van Steeg, H., Hoeijmakers, J.H.J.
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161687/
https://ncbi.nlm.nih.gov/pubmed/27556946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature19329
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