Diet restriction delays accelerated aging and genomic stress in DNA repair deficient mice

DNA repair-deficient Ercc1(Δ/−) mice show numerous accelerated aging features limiting lifespan to 4–6 month(1–4). Simultaneously they exhibit a ‘survival response’, which suppresses growth and enhances maintenance, resembling the anti-aging response induced by dietary restriction (DR)(1,5). Here we...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nature
Main Authors: Vermeij, W.P., Dollé, M.E.T., Reiling, E., Jaarsma, D., Payan-Gomez, C., Bombardieri, C.R., Wu, H., Roks, A.J.M., Botter, S.M., van der Eerden, B.C., Youssef, S.A., Kuiper, R.V., Nagarajah, B., van Oostrom, C.T., Brandt, R.M.C., Barnhoorn, S., Imholz, S., Pennings, J.L.A., de Bruin, A., Gyenis, Á., Pothof, J., Vijg, J., van Steeg, H., Hoeijmakers, J.H.J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161687/
https://ncbi.nlm.nih.gov/pubmed/27556946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature19329
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados