Atrial Heterogeneity Generates Re-entrant Substrate during Atrial Fibrillation and Anti-arrhythmic Drug Action: Mechanistic Insights from Canine Atrial Models

Anti-arrhythmic drug therapy is a frontline treatment for atrial fibrillation (AF), but its success rates are highly variable. This is due to incomplete understanding of the mechanisms of action of specific drugs on the atrial substrate at different stages of AF progression. We aimed to elucidate th...

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Bibliographic Details
Published in:PLoS Comput Biol
Main Authors: Varela, Marta, Colman, Michael A., Hancox, Jules C., Aslanidi, Oleg V.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161306/
https://ncbi.nlm.nih.gov/pubmed/27984585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005245
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