Molecular liver cancer prevention in cirrhosis by organ transcriptome analysis and lysophosphatidic acid pathway inhibition

Cirrhosis is a milieu that develops hepatocellular carcinoma (HCC), the second most lethal cancer worldwide. HCC prediction and prevention in cirrhosis are key unmet medical needs. Here we have established an HCC risk gene signature applicable to all major HCC etiologies: hepatitis B/C, alcohol, and...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Nakagawa, Shigeki, Wei, Lan, Song, Won Min, Higashi, Takaaki, Ghoshal, Sarani, Kim, Rosa S, Bian, C Billie, Yamada, Suguru, Sun, Xiaochen, Venkatesh, Anu, Goossens, Nicolas, Bain, Gretchen, Lauwers, Gregory Y, Koh, Anna P, El-Abtah, Mohamed, Ahmad, Noor B, Hoshida, Hiroki, Erstad, Derek J, Gunasekaran, Ganesh, Lee, Youngmin, Yu, Ming-Lung, Chuang, Wan-Long, Dai, Chia-Yen, Kobayashi, Masahiro, Kumada, Hiromitsu, Beppu, Toru, Baba, Hideo, Mahajan, Milind, Nair, Venugopalan D, Lanuti, Michael, Villanueva, Augusto, Sangiovanni, Angelo, Iavarone, Massimo, Colombo, Massimo, Llovet, Josep M, Subramanian, Aravind, Tager, Andrew M, Friedman, Scott L, Baumert, Thomas F, Schwarz, Myron E, Chung, Raymond T, Tanabe, Kenneth K, Zhang, Bin, Fuchs, Bryan C, Hoshida, Yujin
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161110/
https://ncbi.nlm.nih.gov/pubmed/27960085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.11.004
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