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Src Family Kinase Inhibition as a Novel Strategy to Augment Melphalan-Based Regional Chemotherapy of Advanced Extremity Melanoma

BACKGROUND: Src kinase inhibition has been shown to augment the efficacy of chemotherapy. Dasatinib, a dual Src/Abl kinase inhibitor approved for the treatment of CML, is under investigation as monotherapy for tumors with abnormal Src signaling, such as melanoma. The goal of this study was to determ...

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Detalles Bibliográficos
Publicado en:Ann Surg Oncol
Main Authors: Tokuhisa, Yoshihiro, Lidsky, Michael E., Toshimitsu, Hiroaki, Turley, Ryan S., Beasley, Georgia M., Ueno, Tomio, Sharma, Ketan, Augustine, Christina K., Tyler, Douglas S.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161097/
https://ncbi.nlm.nih.gov/pubmed/24281418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1245/s10434-013-3387-6
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