Deterministic Transfection Drives Efficient Nonviral Reprogramming and Uncovers Reprogramming Barriers

Safety concerns and/or the stochastic nature of current transduction approaches have hampered clinical translation of nuclear reprogramming. We report a novel non-viral nanotechnology-based platform permitting deterministic large-scale transfection with single-cell resolution. The superior capabilit...

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Publicado no:Nanomedicine
Main Authors: Gallego-Perez, Daniel, Otero, Jose J., Czeisler, Catherine, Ma, Junyu, Ortiz, Cristina, Gygli, Patrick, Catacutan, Fay Patsy, Gokozan, Hamza Numan, Cowgill, Aaron, Sherwood, Thomas, Ghatak, Subhadip, Malkoc, Veysi, Zhao, Xi, Liao, Wei-Ching, Gnyawali, Surya, Wang, Xinmei, Adler, Andrew F., Leong, Kam, Wulff, Brian, Wilgus, Traci A., Askwith, Candice, Khanna, Savita, Rink, Cameron, Sen, Chandan K., Lee, L. James.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161095/
https://ncbi.nlm.nih.gov/pubmed/26711960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2015.11.015
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