High-intensity meropenem combinations with polymyxin B: new strategies to overcome carbapenem resistance in Acinetobacter baumannii

OBJECTIVES: The pharmacodynamics of polymyxin/carbapenem combinations against carbapenem-resistant Acinetobacter baumannii (CRAB) are largely unknown. Our objective was to determine whether intensified meropenem regimens in combination with polymyxin B enhance killing and resistance suppression of C...

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Veröffentlicht in:J Antimicrob Chemother
Hauptverfasser: Lenhard, Justin R., Bulitta, Jürgen B., Connell, Terry D., King-Lyons, Natalie, Landersdorfer, Cornelia B., Cheah, Soon-Ee, Thamlikitkul, Visanu, Shin, Beom Soo, Rao, Gauri, Holden, Patricia N., Walsh, Thomas J., Forrest, Alan, Nation, Roger L., Li, Jian, Tsuji, Brian T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161044/
https://ncbi.nlm.nih.gov/pubmed/27634916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkw355
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