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Identifying ultrasensitive HGF dose-response functions in a 3D mammalian system for synthetic morphogenesis

Nonlinear responses to signals are widespread natural phenomena that affect various cellular processes. Nonlinearity can be a desirable characteristic for engineering living organisms because it can lead to more switch-like responses, similar to those underlying the wiring in electronics. Steeper fu...

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Vydáno v:Sci Rep
Hlavní autoři: Senthivel, Vivek Raj, Sturrock, Marc, Piedrafita, Gabriel, Isalan, Mark
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159920/
https://ncbi.nlm.nih.gov/pubmed/27982133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39178
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