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A structural insight into the negative effects of opioids in analgesia by modulating the TLR4 signaling: An in silico approach
Opioids are considered the gold standard therapy for pain. However, TLR-dependent negative effects in analgesia have highlighted the complexities in the pharmacodynamics of opioids. While successive studies have reported that morphine and Morphine-3-glucuronide (M3G) activate the TLR4 pathway, the s...
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| Published in: | Sci Rep |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5159903/ https://ncbi.nlm.nih.gov/pubmed/27982096 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39271 |
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