Pharmacological and genetic reappraisals of protease and oxidative stress pathways in a mouse model of obstructive lung diseases

Protease-antiprotease imbalance and oxidative stress are considered to be major pathophysiological hallmarks of severe obstructive lung diseases including chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF), but limited information is available on their direct roles in the regulati...

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Pubblicato in:Sci Rep
Autori principali: Shuto, Tsuyoshi, Kamei, Shunsuke, Nohara, Hirofumi, Fujikawa, Haruka, Tasaki, Yukihiro, Sugahara, Takuya, Ono, Tomomi, Matsumoto, Chizuru, Sakaguchi, Yuki, Maruta, Kasumi, Nakashima, Ryunosuke, Kawakami, Taisei, Suico, Mary Ann, Kondo, Yoshitaka, Ishigami, Akihito, Takeo, Toru, Tanaka, Ken-ichiro, Watanabe, Hiroshi, Nakagata, Naomi, Uchimura, Kohei, Kitamura, Kenichiro, Li, Jian-Dong, Kai, Hirofumi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159865/
https://ncbi.nlm.nih.gov/pubmed/27982104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39305
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