Role of proteasome-dependent protein degradation in long-term operant memory in Aplysia

We investigated the in vivo role of protein degradation during intermediate (ITM) and long-term memory (LTM) in Aplysia using an operant learning paradigm. The proteasome inhibitor MG-132 inhibited the induction and molecular consolidation of LTM with no effect on ITM. Remarkably, maintenance of ste...

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Vydáno v:Learn Mem
Hlavní autoři: Lyons, Lisa C., Gardner, Jacob S., Gandour, Catherine E., Krishnan, Harini C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2017
Témata:
Brief Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159658/
https://ncbi.nlm.nih.gov/pubmed/27980077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/lm.043794.116
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