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HIV-1 Reverse Transcriptase Polymerase and RNase H (Ribonuclease H) Active Sites Work Simultaneously and Independently

HIV reverse transcriptase plays a central role in viral replication and requires coordination of both polymerase and RNase H activities. Although this coordination is crucial in viral replication, whether a DNA/RNA hybrid can simultaneously engage both active sites has yet to be determined as struct...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Li, An, Li, Jiawen, Johnson, Kenneth A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159515/
https://ncbi.nlm.nih.gov/pubmed/27777303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.753160
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