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Tumour MLH1 promoter region methylation testing is an effective pre-screen for Lynch Syndrome (HNPCC)
BACKGROUND & AIMS: Lynch syndrome patients have DNA mismatch repair deficiency and up to 80% life-time risk of colorectal cancer. Screening of mutation carriers reduces colorectal cancer incidence and mortality. Selection for constitutional mutation testing relies on family history (Amsterdam an...
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| Publicado no: | J Med Genet |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5159427/ https://ncbi.nlm.nih.gov/pubmed/25280751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmedgenet-2014-102552 |
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