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Concurrent Treatment with Taxifolin and Cilostazol on the Lowering of β-Amyloid Accumulation and Neurotoxicity via the Suppression of P-JAK2/P-STAT3/NF-κB/BACE1 Signaling Pathways

Taxifolin is a potent flavonoid that exerts anti-oxidative effect, and cilostazol increases intracellular cAMP levels by inhibiting phosphodiesterase 3 that shows antiinflammatory actions. BACE1 (β-site APP cleaving enzyme 1) is the rate-limiting enzyme responsible for the β-cleavage of amyloid prec...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Park, So Youn, Kim, Hae Young, Park, Hee Jeong, Shin, Hwa Kyoung, Hong, Ki Whan, Kim, Chi Dae
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5158044/
https://ncbi.nlm.nih.gov/pubmed/27977755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168286
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