The protective role of MLCP-mediated ERM dephosphorylation in endotoxin-induced lung injury in vitro and in vivo

The goal of this study was to investigate the role of MLC phosphatase (MLCP) in a LPS model of acute lung injury (ALI). We demonstrate that ectopic expression of a constitutively-active (C/A) MLCP regulatory subunit (MYPT1) attenuates the ability of LPS to increase endothelial (EC) permeability. Dow...

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Pubblicato in:Sci Rep
Autori principali: Kovacs-Kasa, Anita, Gorshkov, Boris A., Kim, Kyung-Mi, Kumar, Sanjiv, Black, Stephen M., Fulton, David J., Dimitropoulou, Christiana, Catravas, John D., Verin, Alexander D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5157034/
https://ncbi.nlm.nih.gov/pubmed/27976727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39018
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