Mutations in conserved yeast DNA primase domains impair DNA replication in vivo.
To assess the role of eukaryotic DNA primase in vivo, we have produced conditional and lethal point mutations by random in vitro mutagenesis of the PR11 and PR12 genes, which encode the small and large subunits of yeast DNA primase. We replaced the wild-type copies of PRI1 and PRI2 with two pri1 and...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1991
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51556/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2023935/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.9.3877 |
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