GLP-1(32–36)amide, a novel pentapeptide cleavage product of GLP-1, modulates whole body glucose metabolism in dogs

We have previously demonstrated in human subjects who under euglycemic clamp conditions GLP-1(9–36)amide infusions inhibit endogenous glucose production without substantial insulinotropic effects. An earlier report indicates that GLP-1(9–36)amide is cleaved to a nonapeptide, GLP-1(28–36)amide and a...

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Udgivet i:Peptides
Main Authors: Elahi, Dariush, Angeli, Franca S., Vakilipour, Amin, Carlson, Olga D., Tomas, Eva, Egan, Josephine M., Habener, Joel F., Shannon, Richard P.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5155305/
https://ncbi.nlm.nih.gov/pubmed/24937653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2014.06.004
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