Adiponectin Protects against Glutamate-Induced Excitotoxicity via Activating SIRT1-Dependent PGC-1α Expression in HT22 Hippocampal Neurons

Glutamate- (Glu-) induced excitotoxicity plays a critical role in stroke. This study aimed to investigate the effects of APN on Glu-induced injury in HT22 neurons. HT22 neurons were treated with Glu in the absence or the presence of an APN peptide. Cell viability was assessed using the MTT assay, wh...

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Pubblicato in:Oxid Med Cell Longev
Autori principali: Yue, Liang, Zhao, Lei, Liu, Haixiao, Li, Xia, Wang, Bodong, Guo, Hao, Gao, Li, Feng, Dayun, Qu, Yan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5155107/
https://ncbi.nlm.nih.gov/pubmed/28042384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/2957354
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