Acute Treatment with Minocycline, but not Valproic Acid, Improves Long-Term Behavioral Outcomes in the Theiler’s Virus Model of Temporal Lobe Epilepsy

OBJECTIVE: Infection with Theiler’s murine encephalomyelitis virus (TMEV) in C57Bl/6J mice induces acute seizures and development of spontaneous recurrent seizures and behavioral comorbidities weeks later. The present studies sought to determine whether acute therapeutic intervention with an anti-in...

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Pubblicato in:Epilepsia
Autori principali: Barker-Haliski, Melissa L., Heck, Taylor D., Dahle, E. Jill, Vanegas, Fabiola, Pruess, Timothy H., Wilcox, Karen S., White, H. Steve
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154893/
https://ncbi.nlm.nih.gov/pubmed/27739576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.13577
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