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Prophylactic treatment with the tricyclic antidepressant desipramine prevents development of paclitaxel-induced neuropathic pain through activation of endogenous analgesic systems

Neuropathic pain impacts approximately 3–4.5% of the global population and remains an unresolved health problem. The management of neuropathic pain has two distinct goals—prevention of development and control of established neuropathic pain. We examined the impact of both prophylactic and therapeuti...

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Detalhes bibliográficos
Publicado no:Pharmacol Res
Main Authors: Deng, Liting, Lee, Wan-Hung, Xu, Zhili, Makriyannis, Alexandros, Hohmann, Andrea G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154848/
https://ncbi.nlm.nih.gov/pubmed/27773824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2016.10.007
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