Stimuli-responsive hybrid nanocarriers developed by controllable integration of hyperbranched PEI with mesoporous silica nanoparticles for sustained intracellular siRNA delivery

Small interfering RNA (siRNA) is a highly potent drug in gene-based therapy with the challenge being to deliver it in a sustained manner. The combination of mesoporous silica nanoparticles (MSNs) and polycations in the confined pore space allows for incorporation and controlled release of therapeuti...

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Bibliographische Detailangaben
Veröffentlicht in:Int J Nanomedicine
Hauptverfasser: Prabhakar, Neeraj, Zhang, Jixi, Desai, Diti, Casals, Eudald, Gulin-Sarfraz, Tina, Näreoja, Tuomas, Westermarck, Jukka, Rosenholm, Jessica M
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2016
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154729/
https://ncbi.nlm.nih.gov/pubmed/27994460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S120611
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