In Vivo Gene Delivery to Lymph Node Stromal Cells Leads to Transgene-specific CD8+ T Cell Anergy in Mice

Lymph node stromal cells play a role in self-tolerance by presenting tissue antigens to T cells. Yet, immunomodulatory properties of lymphoid tissue stroma, particularly toward CD4+ T cells, remain insufficiently characterized by lack of tools to target antigens for presentation by stromal cells. A...

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Bibliographic Details
Published in:Mol Ther
Main Authors: Ciré, Séverine, Da Rocha, Sylvie, Ferrand, Maxime, Collins, Mary K, Galy, Anne
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154481/
https://ncbi.nlm.nih.gov/pubmed/27562586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.168
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