Priming of Natural Killer cells by Interleukin-18

Recent evidence suggests that NK cells require priming to display full effector activity. Here, we demonstrate that IL-18 contributed to this phenomenon. IL-18 signalling-deficient NK cells were found to be unable to secrete IFN-γ in response to ex vivo stimulation with IL-12. This was not due to a...

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Udgivet i:J Immunol
Main Authors: Chaix, Julie, Tessmer, Marlowe S., Hoebe, Kasper, Fuséri, Nicolas, Ryffel, Bernhard, Dalod, Marc, Alexopoulou, Lena, Beutler, Bruce, Brossay, Laurent, Vivier, Eric, Walzer, Thierry
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154249/
https://ncbi.nlm.nih.gov/pubmed/18641298
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