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The ability of human nuclear DNA to cause false positive low-abundance heteroplasmy calls varies across the mitochondrial genome

BACKGROUND: Low-abundance mutations in mitochondrial populations (mutations with minor allele frequency ≤ 1%), are associated with cancer, aging, and neurodegenerative disorders. While recent progress in high-throughput sequencing technology has significantly improved the heteroplasmy identification...

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Detaylı Bibliyografya
Yayımlandı:BMC Genomics
Asıl Yazarlar: Albayrak, Levent, Khanipov, Kamil, Pimenova, Maria, Golovko, George, Rojas, Mark, Pavlidis, Ioannis, Chumakov, Sergei, Aguilar, Gerardo, Chávez, Arturo, Widger, William R., Fofanov, Yuriy
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5153897/
https://ncbi.nlm.nih.gov/pubmed/27955616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-016-3375-x
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