Low kidney uptake of GLP-1R-targeting, beta cell-specific PET tracer, (18)F-labeled [Nle(14),Lys(40)]exendin-4 analog, shows promise for clinical imaging

BACKGROUND: Several radiometal-labeled, exendin-based tracers that target glucagon-like peptide-1 receptors (GLP-1R) have been intensively explored for β cell imaging. The main obstacle has been the high uptake of tracer in the kidneys. This study aimed to develop a novel GLP1-R-specific tracer, wit...

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Bibliografiske detaljer
Udgivet i:EJNMMI Res
Main Authors: Mikkola, Kirsi, Yim, Cheng-Bin, Lehtiniemi, Paula, Kauhanen, Saila, Tarkia, Miikka, Tolvanen, Tuula, Nuutila, Pirjo, Solin, Olof
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2016
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5153397/
https://ncbi.nlm.nih.gov/pubmed/27957723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-016-0243-2
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