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The Cochaperone HspBP1 Inhibits the CHIP Ubiquitin Ligase and Stimulates the Maturation of the Cystic Fibrosis Transmembrane Conductance Regulator

The CHIP ubiquitin ligase turns molecular chaperones into protein degradation factors. CHIP associates with the chaperones Hsc70 and Hsp90 during the regulation of signaling pathways and during protein quality control, and directs chaperone-bound clients to the proteasome for degradation. Obviously,...

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Detalhes bibliográficos
Main Authors: Alberti, Simon, Böhse, Karsten, Arndt, Verena, Schmitz, Anton, Höhfeld, Jörg
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2004
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC515335/
https://ncbi.nlm.nih.gov/pubmed/15215316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-04-0293
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