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Genome-Scale In Silico Models of E. coli Have Multiple Equivalent Phenotypic States: Assessment of Correlated Reaction Subsets That Comprise Network States

The constraint-based analysis of genome-scale metabolic and regulatory networks has been successful in predicting phenotypes and useful for analyzing high-throughput data sets. Within this modeling framework, linear optimization has been used to study genome-scale metabolic models, resulting in the...

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Autori principali: Reed, Jennifer L., Palsson, Bernhard Ø.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC515326/
https://ncbi.nlm.nih.gov/pubmed/15342562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.2546004
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