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Evolutionarily conserved sequence elements that positively regulate IFN-γ expression in T cells

Our understanding of mechanisms by which the expression of IFN-γ is regulated is limited. Herein, we identify two evolutionarily conserved noncoding sequence elements (IFNgCNS1 and IFNg CNS2) located ≈5 kb upstream and ≈18 kb downstream of the initiation codon of the murine Ifng gene. When linked to...

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Detalhes bibliográficos
Main Authors: Shnyreva, Maria, Weaver, William M., Blanchette, Mathieu, Taylor, Scott L., Tompa, Martin, Fitzpatrick, David R., Wilson, Christopher B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC515107/
https://ncbi.nlm.nih.gov/pubmed/15304658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400849101
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