Granulocyte-Macrophage Colony-Stimulating Factor Enhancer Activation Requires Cooperation between NFAT and AP-1 Elements and Is Associated with Extensive Nucleosome Reorganization

The human granulocyte-macrophage colony-stimulating factor (GM-CSF) gene is activated by an NFAT-dependent enhancer forming an inducible DNase I hypersensitive (DH) site. The enhancer core comprising the DH site contains the GM330 and GM420 elements that bind NFAT and AP-1 cooperatively. Here we dem...

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Bibliographische Detailangaben
Hauptverfasser: Johnson, Brett V., Bert, Andrew G., Ryan, Gregory R., Condina, Antony, Cockerill, Peter N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Transcriptional Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC515070/
https://ncbi.nlm.nih.gov/pubmed/15340054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.18.7914-7930.2004
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