Discovery of Potent and Selective Leads against Toxoplasma gondii Dihydrofolate Reductase via Structure-Based Design

[Image: see text] Current treatment of toxoplasmosis targets the parasite’s folate metabolism through inhibition of dihydrofolate reductase (DHFR). The most widely used DHFR antagonist, pyrimethamine, was introduced over 60 years ago and is associated with toxicity that can be largely attributed to...

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Bibliografiske detaljer
Udgivet i:ACS Med Chem Lett
Main Authors: Welsch, Matthew E., Zhou, Jian, Gao, Yueqiang, Yan, Yunqing, Porter, Gene, Agnihotri, Gautam, Li, Yingjie, Lu, Henry, Chen, Zhongguo, Thomas, Stephen B.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2016
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150685/
https://ncbi.nlm.nih.gov/pubmed/27994750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00328
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