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A Single Pulse of Agrin Triggers a Pathway That Acts To Cluster Acetylcholine Receptors

Agrin triggers signaling mechanisms of high temporal and spatial specificity to achieve phosphorylation, clustering, and stabilization of postsynaptic acetylcholine receptors (AChRs). Agrin transiently activates the kinase MuSK; MuSK activation has largely vanished when AChR clusters appear. Thus, a...

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Autori principali: Mittaud, Peggy, Camilleri, Alain A., Willmann, Raffaella, Erb-Vögtli, Susanne, Burden, Steven J., Fuhrer, Christian
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC515067/
https://ncbi.nlm.nih.gov/pubmed/15340048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.18.7841-7854.2004
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