Epstein–Barr virus super-enhancer eRNAs are essential for MYC oncogene expression and lymphoblast proliferation

Epstein–Barr virus (EBV) super-enhancers (ESEs) are essential for lymphoblastoid cell (LCL) growth and survival. Reanalyses of LCL global run-on sequencing (Gro-seq) data found abundant enhancer RNAs (eRNAs) being transcribed at ESEs. Inactivation of ESE components, EBV nuclear antigen 2 (EBNA2) and...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Liang, Jun, Zhou, Hufeng, Gerdt, Catherine, Tan, Min, Colson, Tyler, Kaye, Kenneth M., Kieff, Elliott, Zhao, Bo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150416/
https://ncbi.nlm.nih.gov/pubmed/27864512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616697113
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