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On the (un)predictability of a large intragenic fitness landscape

The study of fitness landscapes, which aims at mapping genotypes to fitness, is receiving ever-increasing attention. Novel experimental approaches combined with next-generation sequencing (NGS) methods enable accurate and extensive studies of the fitness effects of mutations, allowing us to test the...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bank, Claudia, Matuszewski, Sebastian, Hietpas, Ryan T., Jensen, Jeffrey D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150413/
https://ncbi.nlm.nih.gov/pubmed/27864516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612676113
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