Synergistic Cytotoxic Effect of L-Asparaginase Combined with Decitabine as a Demethylating Agent in Pediatric T-ALL, with Specific Epigenetic Signature

T-Acute Lymphoblastic Leukemia (T-ALL) remains a subgroup of pediatric ALL, with a lower response to standard chemotherapy. Some recent studies established the fundamental role of epigenetic aberrations such as DNA hypermethylation, to influence patients' outcome and response to chemotherapy. M...

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Publicat a:Biomed Res Int
Autors principals: Serravalle, Salvatore, Bertuccio, Salvatore N., Astolfi, Annalisa, Melchionda, Fraia, Pession, Andrea
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150123/
https://ncbi.nlm.nih.gov/pubmed/28003999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/1985750
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