A Naturally Occurring Variation in the Proline-Rich Region Does Not Attenuate Human Immunodeficiency Virus Type 1 Nef Function

We analyzed human immunodeficiency virus type 1 (HIV-1) Nef variants to further evaluate the functional relevance of the R71T substitution previously proposed to attenuate viral replication (Fackler et al., Curr. Biol. 11:1294-1299, 2001). Our results demonstrate that this variation in the proline-r...

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Main Authors: Rücker, Elke, Münch, Jan, Wildum, Steffen, Brenner, Matthias, Eisemann, Jutta, Margolis, Leonid, Kirchhoff, Frank
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2004
Assuntos:
Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC514962/
https://ncbi.nlm.nih.gov/pubmed/15331753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.18.10197-10201.2004
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