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Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA-1 and GATA-2

How does an emerging transcriptional programme regulate individual genes as stem cells undergo lineage commitment, differentiation and maturation? To answer this, we have analysed the dynamic protein/DNA interactions across 130 kb of chromatin containing the mouse α-globin cluster in cells represent...

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Hlavní autoři: Anguita, Eduardo, Hughes, Jim, Heyworth, Clare, Blobel, Gerd A, Wood, William G, Higgs, Douglas R
Médium: Artigo
Jazyk:Inglês
Vydáno: 2004
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC514941/
https://ncbi.nlm.nih.gov/pubmed/15215894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600274
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