STAT3 signaling drives EZH2 transcriptional activation and mediates poor prognosis in gastric cancer

BACKGROUND: STAT3 signaling plays the pivotal role in tumorigenesis through EZH2 epigenetic modification, which enhanced STAT3 activity by increased tyrosine phosphorylation of STAT3. Here, another possible feedback mechanism and clinical significance of EZH2 and STAT3 were investigated in gastric c...

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Bibliografiska uppgifter
I publikationen:Mol Cancer
Huvudupphovsmän: Pan, Yuan-Ming, Wang, Cheng-Gang, Zhu, Min, Xing, Rui, Cui, Jian-Tao, Li, Wen-Mei, Yu, De-Dong, Wang, Shu-Bin, Zhu, Wei, Ye, Ying-Jiang, Wu, Yun, Wang, Shan, Lu, You-Yong
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2016
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148878/
https://ncbi.nlm.nih.gov/pubmed/27938379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-016-0561-z
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