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The effects of reduced dopamine transporter function and chronic lithium on motivation, probabilistic learning, and neurochemistry in mice: Modeling bipolar mania

BACKGROUND: Bipolar disorder (BD) mania patients exhibit poor cognition and reward-seeking/hypermotivation, negatively impacting a patient’s quality of life. Current treatments (e.g., lithium), do not treat such deficits. Treatment development has been limited due to a poor understanding of the neur...

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Detalhes bibliográficos
Publicado no:Neuropharmacology
Main Authors: Milienne-Petiot, Morgane, Kesby, James P., Graves, Mary, van Enkhuizen, Jordy, Semenova, Svetlana, Minassian, Arpi, Markou, Athina, Geyer, Mark A., Young, Jared W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148687/
https://ncbi.nlm.nih.gov/pubmed/27732870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2016.07.030
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