p39 Is Responsible for Increasing Cdk5 Activity during Postnatal Neuron Differentiation and Governs Neuronal Network Formation and Epileptic Responses

Two distinct protein cofactors, p35 and p39, independently activate Cyclin-dependent kinase 5 (Cdk5), which plays diverse roles in normal brain function and the pathogenesis of many neurological diseases. The initial discovery that loss of p35 impairs neuronal migration in the embryonic brain prompt...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Li, Wenqi, Allen, Megan E., Rui, Yanfang, Ku, Li, Liu, Guanglu, Bankston, Andrew N., Zheng, James Q., Feng, Yue
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148244/
https://ncbi.nlm.nih.gov/pubmed/27807169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1155-16.2016
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