The Novel Azole R126638 Is a Selective Inhibitor of Ergosterol Synthesis in Candida albicans, Trichophyton spp., and Microsporum canis

R126638 is a novel triazole with in vitro activity similar to that of itraconazole against dermatophytes, Candida spp., and Malassezia spp. In animal models of dermatophyte infections, R126638 showed superior antifungal activity. R126638 inhibits ergosterol synthesis in Candida albicans, Trichophyto...

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Autori principali: Vanden Bossche, Hugo, Ausma, Jannie, Bohets, Hilde, Vermuyten, Karen, Willemsens, Gustaaf, Marichal, Patrick, Meerpoel, Lieven, Odds, Frank, Borgers, Marcel
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2004
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Mechanisms of Action: Physiological Effects
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC514767/
https://ncbi.nlm.nih.gov/pubmed/15328084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.9.3272-3278.2004
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