The Novel Azole R126638 Is a Selective Inhibitor of Ergosterol Synthesis in Candida albicans, Trichophyton spp., and Microsporum canis

R126638 is a novel triazole with in vitro activity similar to that of itraconazole against dermatophytes, Candida spp., and Malassezia spp. In animal models of dermatophyte infections, R126638 showed superior antifungal activity. R126638 inhibits ergosterol synthesis in Candida albicans, Trichophyto...

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Main Authors: Vanden Bossche, Hugo, Ausma, Jannie, Bohets, Hilde, Vermuyten, Karen, Willemsens, Gustaaf, Marichal, Patrick, Meerpoel, Lieven, Odds, Frank, Borgers, Marcel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC514767/
https://ncbi.nlm.nih.gov/pubmed/15328084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.9.3272-3278.2004
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