The Novel Azole R126638 Is a Selective Inhibitor of Ergosterol Synthesis in Candida albicans, Trichophyton spp., and Microsporum canis

R126638 is a novel triazole with in vitro activity similar to that of itraconazole against dermatophytes, Candida spp., and Malassezia spp. In animal models of dermatophyte infections, R126638 showed superior antifungal activity. R126638 inhibits ergosterol synthesis in Candida albicans, Trichophyto...

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Bibliografski detalji
Glavni autori: Vanden Bossche, Hugo, Ausma, Jannie, Bohets, Hilde, Vermuyten, Karen, Willemsens, Gustaaf, Marichal, Patrick, Meerpoel, Lieven, Odds, Frank, Borgers, Marcel
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2004
Teme:
Mechanisms of Action: Physiological Effects
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC514767/
https://ncbi.nlm.nih.gov/pubmed/15328084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.9.3272-3278.2004
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