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The Melaminophenyl Arsenicals Melarsoprol and Melarsen Oxide Interfere with Thiamine Metabolism in the Fission Yeast Schizosaccharomyces pombe
The melaminophenyl arsenical melarsoprol is the main drug used against late-stage sleeping sickness caused by Trypanosoma brucei subspecies. Its active metabolite in the human body is melarsen oxide. Here, it is shown that this metabolite inhibits growth of the fission yeast Schizosaccharomyces pomb...
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| 第一著者: | |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology
2004
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| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC514754/ https://ncbi.nlm.nih.gov/pubmed/15328083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.9.3268-3271.2004 |
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