IL-17 receptor signaling in oral epithelial cells is critical for protection against oropharyngeal candidiasis

Signaling through the IL-17 receptor (IL-17R) is required to prevent oropharyngeal candidiasis (OPC) in mice and humans. However, the IL-17-responsive cell type(s) that mediate protection are unknown. Using radiation chimeras we were able to rule out a requirement for IL-17RA in the hematopoietic co...

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Publicat a:Cell Host Microbe
Autors principals: Conti, Heather R., Bruno, Vincent M., Childs, Erin E., Daugherty, Sean, Hunter, Joseph P., Mengesha, Bemnet G., Saevig, Danielle L., Hendricks, Matthew R., Coleman, Bianca M., Brane, Lucas, Solis, Norma, Cruz, J. Agustin, Verma, Akash H., Garg, Abhishek V., Hise, Amy G., Richardson, Jonathan P., Naglik, Julian R., Filler, Scott G., Kolls, Jay K., Sinha, Satrajit, Gaffen, Sarah L.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5147498/
https://ncbi.nlm.nih.gov/pubmed/27923704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2016.10.001
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