Single‐cell sequencing maps gene expression to mutational phylogenies in PDGF‐ and EGF‐driven gliomas

Glioblastoma multiforme (GBM) is the most common and aggressive type of primary brain tumor. Epidermal growth factor (EGF) and platelet‐derived growth factor (PDGF) receptors are frequently amplified and/or possess gain‐of‐function mutations in GBM. However, clinical trials of tyrosine‐kinase inhibi...

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Bibliografiske detaljer
Udgivet i:Mol Syst Biol
Main Authors: Müller, Sören, Liu, Siyuan John, Di Lullo, Elizabeth, Malatesta, Martina, Pollen, Alex A, Nowakowski, Tomasz J, Kohanbash, Gary, Aghi, Manish, Kriegstein, Arnold R, Lim, Daniel A, Diaz, Aaron
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5147052/
https://ncbi.nlm.nih.gov/pubmed/27888226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20166969
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