Anti-C1q autoantibodies deposit in glomeruli but are only pathogenic in combination with glomerular C1q-containing immune complexes

Anti-C1q autoantibodies are present in sera of patients with several autoimmune diseases, including systemic lupus erythematosus (SLE). Strikingly, in SLE the presence of anti-C1q is associated with the occurrence of nephritis. We have generated mouse anti–mouse C1q mAb’s and used murine models to i...

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Hauptverfasser: Trouw, Leendert A., Groeneveld, Tom W.L., Seelen, Marc A., Duijs, Jacques M.G.J., Bajema, Ingeborg M., Prins, Frans A., Kishore, Uday, Salant, David J., Verbeek, J. Sjef, Kooten, Cees van, Daha, Mohamed R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2004
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC514584/
https://ncbi.nlm.nih.gov/pubmed/15343386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421075
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