Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy

The current widespread outbreak of Zika virus (ZIKV) infection has been linked to severe clinical birth defects, particularly microcephaly, warranting urgent study of the molecular mechanisms underlying ZIKV pathogenesis. Akt-mTOR signaling is one of the key cellular pathways essential for brain dev...

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Publicado no:Cell Stem Cell
Main Authors: Liang, Qiming, Luo, Zhifei, Zeng, Jianxiong, Chen, Weiqiang, Foo, Suan-Sin, Lee, Shin-Ae, Ge, Jianning, Wang, Su, Goldman, Steven A., Zlokovic, Berislav V., Zhao, Zhen, Jung, Jae U.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5144538/
https://ncbi.nlm.nih.gov/pubmed/27524440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.07.019
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