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Inhibiting macrophage PI3Kγ to enhance immunotherapy
A recent paper published in Nature reports that the immunosuppressive activity of tumor-associated macrophages is regulated via PI3Kγ signaling. Small-molecule inhibitors targeting PI3Kγ stimulate T cell activity against tumor alone and add additional effects for clinically proven PD1 immunotherapy....
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| Publicado no: | Cell Res |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5143418/ https://ncbi.nlm.nih.gov/pubmed/27834344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2016.132 |
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