Anti-TNFα alters the natural history of experimental Crohn's disease in rats when begun early, but not late, in disease

Anti-TNFα therapy decreases inflammation in Crohn's disease (CD). However, its ability to decrease fibrosis and alter the natural history of CD is not established. Anti-TNF-α prevents inflammation and fibrosis in the peptidoglycan-polysaccharide (PG-PS) model of CD. Here we studied anti-TNF-α i...

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Detalhes bibliográficos
Publicado no:Am J Physiol Gastrointest Liver Physiol
Principais autores: Schmiedlin-Ren, Phyllissa, Reingold, Laura J., Broxson, Christopher S., Rittershaus, Ahren C., Brudi, Josh S., Adler, Jeremy, Owens, Scott R., Zimmermann, Ellen M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2016
Assuntos:
Inflammation, Immunity, Fibrosis, and Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142192/
https://ncbi.nlm.nih.gov/pubmed/27562059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00216.2015
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