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A Functional Variant Associated with Atrial Fibrillation Regulates PITX2c Expression through TFAP2a

The most significantly associated genetic locus for atrial fibrillation (AF) is in chromosomal region 4q25, where four independent association signals have been identified. Although model-system studies suggest that altered PITX2c expression might underlie the association, the link between specific...

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Detalhes bibliográficos
Publicado no:Am J Hum Genet
Main Authors: Ye, Jiangchuan, Tucker, Nathan R., Weng, Lu-Chen, Clauss, Sebastian, Lubitz, Steven A., Ellinor, Patrick T.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142106/
https://ncbi.nlm.nih.gov/pubmed/27866707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2016.10.001
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